ARCI Uniform Classification Guidelines for Foreign Substances

Preamble to the Uniform Classification Guidelines of Foreign Substances . ii Notes Regarding Classification Guidelines . ii Classification Criteria . iii Classification Definitions . iv Drug Classification Scheme . vi Alphabetical Substance List . 1 Listing by Classification . 13 Non-Classified Substances . 27 Recommended Penalty and Model Rule . 28 Recent Document Revisions . 32

Association of Racing Commissioners International, Inc. Page i Uniform Classification Guidelines for Foreign Substances

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Preamble to the Uniform Classification Guidelines of Foreign Substances

The Preamble to the Uniform Classification Guidelines was approved by the RCI Drug Testing and Quality Assurance Program Committee (now the Drug Testing Standards and Practices Program Committee) on August 26, 1991. Minor revisions to the Preamble were made by the Drug Classification subcommittee (now the Veterinary Pharmacologists Subcommittee) on September 3, 1991.

"The Uniform Classification Guidelines printed on the following pages are intended to assist stewards, hearing officers and racing commissioners in evaluating the seriousness of alleged violations of medication and prohibited substance rules in racing jurisdictions. Practicing equine veterinarians, state veterinarians, and equine pharmacologists are available and should be consulted to explain the pharmacological effects of the drugs listed in each class prior to any decisions with respect to penalities to be imposed. The ranking of drugs is based on their pharmacology, their ability to influence the outcome of a race, whether or not they have legitimate therapeutic uses in the racing horse, or other evidence that they may be used improperly. These classes of drugs are intended only as guidelines and should be employed only to assist persons adjudicating facts and opinions in understanding the seriousness of the alleged offenses. The facts of each case are always different and there may be mitigating circumstances which should always be considered. These drug classifications will be reviewed frequently and new drugs will be added when appropriate."

Notes Regarding Classification Guidelines

 Where the use of a drug is specifically permitted by a jurisdiction, then the jurisdiction’s rule supersedes these penalty guidelines.

 Regulators should be aware that a laboratory report may identify a drug only by the name of its metabolite. The metabolite might not be listed here, but the parent compound may be.

 These classes of drugs are intended only as guidelines and should be employed only to assist persons adjudicating facts and opinions in understanding the seriousness of the alleged offenses.

 The facts of each case are different and there may be mitigating circumstances that should be considered.

 These drug classifications will be reviewed periodically. New drugs will be added or some drugs may be reclassified when appropriate.

 Found substances or drugs not included in these guidelines should be treated as Class 1 violations warranting a Class A penalty unless otherwise advised by consultation with Racing Commissioners International (RCI) and/or the Racing Medication and Testing Consortium (RMTC).

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The RCI Drug Classification Scheme is based on 1) pharmacology, 2) drug use patterns, and 3) the appropriateness of a drug for use in the racing horse. Categorization is decided using the following general guidelines:

 Pharmacology. Drugs that are known to be potent stimulants or depressants are placed in higher classes, while those that have (or would be expected to have) little effect on the outcome of a race are placed in lower classes.

 Drug Use Patterns. Some consideration is given to placement of drugs based on practical experience with their use and the nature of positive tests. For example, procaine positives have in the past been associated primarily with the administration of procaine penicillin, and this has been taken into consideration in the placement of procaine into Class 3 instead of Class 2 with other injectable local anesthetics.

 Appropriateness of Drug Use. Drugs that clearly are intended for use in equine therapeutics are placed in lower classes. Drugs that clearly are not intended for use in the horse are placed in higher classes, particularly if they might affect the outcome of a race. Drugs that are recognized as legitimately useful in equine therapeutics but could affect the outcome of a race are placed in the middle or higher classes.

The list includes most drugs that have been reported as detected by racing authority laboratories in the United States, Canada, the United Kingdom and other Association of Official Racing Chemists (AORC) laboratories, but does not include those which would seem to have no effect on the performance of the horse or drug detectability. For example, it does not include antibiotics, sulfonamides, vitamins, anthelmintics, or pangamic acid, all of which have been reported.

The list contains many drugs that have never been reported as detected. Usually, these are representatives of chemical classes that have the potential for producing an effect, and in many cases, for which at least one drug in that chemical class has been reported.

Most drugs have numerous effects, and each was judged on an individual basis. There are instances where there is a rather fine distinction between drugs in one category and those in the next. This is a reflection of a nearly continuous spectrum of effects from the most innocuous drug on the list to the drug that is the most offensive.

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 Class 1: Stimulant and depressant drugs that have the highest potential to affect performance and that have no generally accepted medical use in the racing horse. Many of these agents are Drug Enforcement Agency (DEA) schedule II substances. These include the following drugs and their metabolites: Opiates, opium derivatives, synthetic opioids and psychoactive drugs, amphetamines and amphetamine-like drugs as well as related drugs, including but not limited to apomorphine, nikethamide, mazindol, pemoline, and pentylenetetrazol. Though not used as therapeutic agents, all DEA Schedule 1 agents are included in Class 1 because they are potent stimulant or depressant substances with psychotropic and often habituative actions.

 Class 2: Drugs that have a high potential to affect performance, but less of a potential than drugs in Class 1. These drugs are 1) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse. Drugs in this class include: psychotropic drugs, certain nervous system and cardiovascular system stimulants, depressants, and neuromuscular blocking agents. Injectable local anesthetics are included in this class because of their high potential for abuse as nerve blocking agents.

 Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology of which suggests less potential to affect performance than drugs in Class 2. Drugs in this class include bronchodilators, anabolic steroids and other drugs with primary effects on the autonomic nervous system, procaine, antihistamines with sedative properties and the high-ceiling diuretics.

 Class 4: This class includes therapeutic medications that would be expected to have less potential to affect performance than those in Class 3. Drugs in this class includes less potent diuretics; corticosteroids; antihistamines and skeletal muscle relaxants without prominent central nervous system (CNS) effects; expectorants and mucolytics; hemostatics; cardiac glycosides and anti-arrhythmics; topical anesthetics; antidiarrheals and mild analgesics. This class also includes the non-steroidal anti-inflammatory drugs (NSAIDs), at concentrations greater than established limits.

 Class 5: This class includes those therapeutic medications for which concentration limits have been established by the racing jurisdictions as well as certain miscellaneous agents and other medications as determined by the regulatory bodies. Included specifically are agents that have very localized actions only, such as anti-ulcer drugs, and certain anti-allergic drugs. The anticoagulant drugs are also included.

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 Prohibited Practices: A) The possession and/or use of a drug, substance or medication, specified below, on the premises of a facility under the jurisdiction of the regulatory body for which a recognized analytical method has not been developed to detect and confirm the administration of such substance; or the use of which may endanger the health and welfare of the horse or endanger the safety of the rider or driver; or the use of which may adversely affect the integrity of racing:

1) Erythropoietin 2) Darbepoietin 3) Oxyglobin 4) Hemopure

B) The possession and/or use of a drug, substance, or medication on the premises of a facility under the jurisdiction of the regulatory body that has not been approved by the United States Food and Drug Administration (FDA) for use in the United States.

C) The practice, administration, or application of a treatment, procedure, therapy or method identified below, which is performed on the premises of a facility under jurisdiction of a regulatory body and which may endanger the health and welfare of the horse or endanger the safety of the rider or driver, or the use of which may adversely affect the integrity of racing:

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Drug Classification Scheme

 Class 1: Opiates, opium derivatives, synthetic opioids, psychoactive drugs, amphetamines, and all DEA Schedule I substances (see http://www.deadiversion.usdoj.gov/schedules/#list), and many DEA Schedule II drugs. Also found in this class are drugs that are potent stimulants of the CNS. Drugs in this class have no generally accepted medical use in the racing horse and their pharmacologic potential for altering the performance of a racing horse is very high.

 Class 2: Drugs placed in this category have a high potential for affecting the outcome of a race. Most are not generally accepted as therapeutic agents in the racing horse. Many are products intended to alter consciousness or the psychic state of humans, and have no approved or indicated use in the horse. Some, such as injectable local anesthetics, have legitimate use in equine medicine, but should not be found in a racing horse. The following groups of drugs are placed in this class:

A. Opiate partial agonists, or agonist-antagonists. B. Non-opiate psychotropic drugs. These drugs may have stimulant, depressant, analgesic or neuroleptic effects. C. Miscellaneous drugs, which might have a stimulant effect on the CNS. D. Drugs with prominent CNS depressant action. E. Anti-depressant and antipsychotic drugs, with or without prominent CNS stimulatory or depressant effects. F. Muscle blocking drugs - those that have a direct neuromuscular blocking action. G. Local anesthetics that have a reasonable potential for use as nerve-blocking agents (except procaine). H. Snake venoms and other biologic substances that may be used as nerve-blocking agents.

 Class 3: Drugs placed in this class may or may not have an accepted therapeutic use in the horse. Many are drugs that affect the cardiovascular, pulmonary and autonomic nervous systems. They all have the potential of affecting the performance of a racing horse. The following groups of drugs are placed in this class:

A. Drugs affecting the autonomic nervous system that do not have prominent CNS effects, but which do have prominent cardiovascular or respiratory system effects. Bronchodilators are included in this class. B. A local anesthetic that has nerve-blocking potential but also has a high potential for producing urine residue levels from a method of use not related to the anesthetic effect of the drug (procaine). C. Miscellaneous drugs with mild sedative action, such as the sleep-inducing antihistamines. D. Primary vasodilating/hypotensive agents. E. Potent diuretics affecting renal function and body fluid composition. F. Anabolic and/or androgenic steroids and other drugs.

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 Class 4: Drugs in this category comprise primarily therapeutic medications routinely used in racehorses. These may influence performance, but generally have a more limited ability to do so. Groups of drugs assigned to this category include the following:

A. Non-opiate drugs that have a mild central antipyretic effect. B. Drugs affecting the autonomic nervous system that do not have prominent CNS, cardiovascular, or respiratory effects: 1. Drugs used solely as topical vasoconstrictors or decongestants. 2. Drugs used as gastrointestinal antispasmodics. 3. Drugs used to void the urinary bladder. 4. Drugs with a major effect on CNS vasculature or smooth muscle of visceral organs. C. Antihistamines that do not have a significant CNS depressant effect. This does not include the H2 blocking agents, which are in Class 5. D. Mineralocorticoid drugs. E. Skeletal muscle relaxants. F. Anti-inflammatory drugs. These drugs may reduce pain as a consequence of their anti-inflammatory action. 1. Non-steroidal anti-inflammatory drugs (NSAIDs). (Aspirin-like drugs). 2. Corticosteroids (glucocorticoids). 3. Miscellaneous anti-inflammatory agents. G. Less potent diuretics. H. Cardiac glycosides and antiarrhythmic agents. 1. Cardiac glycosides. 2. Antiarrhythmic agents (exclusive of lidocaine, bretylium, and propranolol). 3. Miscellaneous cardiotonic drugs. I. Topical Anesthetics - agents not available in injectable formulations. J. Antidiarrheal drugs. K. Miscellaneous drugs: 1. Expectorants with little or no other pharmacologic action. 2. Stomachics. 3. Mucolytic agents.

 Class 5: Drugs in this category are therapeutic medications for which concentration limits have been established by the racing jurisdictions as well as certain miscellaneous agents. Included specifically are agents that have very localized actions only, such as anti-ulcer drugs, and certain antiallergic drugs. The anticoagulant drugs are also included.

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Alphabetical Substance List

Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class 2-Aminoheptane Tuamine 4 B Aminoxafen, 3,4-methylenedioxypyprovalerone MDPV, “bath salts” 1 A Aminorex Aminoxaphen, Apiquel, 1 A 3-Methoxytyramine 3-MT 2 A McN-742, Menocil Acebutolol Sectral 3 B Amisometradine Rolictron 4 B Acecarbromal 2 A Amisulpride Solian 2 A Acenocoumarol 5 C Amitraz Mitaban 3 A Atrovet, Notensil, Amitriptyline Elavil, Amitril, Endep 2 A Acepromazine 3 B PromAce® Amlodipine Ammivin, Norvasc 3 B Acetaminophen (Paracetamol) Tylenol, Tempra, etc. 4 C Amobarbital Amytal 2 A Acetanilid 4 B Amoxapine Asendin 2 A Acetazolamide Diamox, Vetamox 4 B Amperozide 2 A Acetophenazine Tindal 2 A Amphetamine 1 A Acetophenetidin (Phenacetin) 4 B Amrinone 4 B Acetylsalicylic acid (Aspirin) 4 C Amyl nitrite 3 A Alclomethasone Aclovate 4 C Anileridine Leritine 1 A Adinazolam 2 A Anilopam Anisine 2 A Adrenochrome monosemicarbazone Anisindione 5 C 4 B salicylate Anisotropine Valpin 4 B Albuterol (Salbutamol) Proventil, Ventolin 3 B Antipyrine 4 B Alclofenac 2 A Apazone (Azapropazone) Rheumox 4 B Alcuronium Alloferin 2 A Apomorphine 1 A Aldosterone Aldocortin, Electrocortin 4 B Aprindine 4 B Alfentanil Alfenta 1 A Aprobarbital Alurate 2 A Almotriptan Axert 3 A Arecoline 3 A Alphaprodine Nisentil 2 A Arformoterol 3 A Alpidem Anaxyl 2 A Articaine Septocaine; Ultracaine, etc. 2 A Alprazolam Xanax 2 A Atenolol Tenormin 3 B Alprenolol 3 A Atomoxetine Strattera 2 A Althesin Saffan 2 A Atracurium Tracrium 2 A Ambenonium Mytelase, Myeuran 3 B Atropine 3 B Ambroxol Ambril, etc. 4 C Azacylonol Frenque 2 A Amcinonide Cyclocort 4 C Stresnil, Suicalm, Fentaz Azaperone 2 A Amiloride Moduretic; Midamor 4 B (with Fentanyl) Aminocaproic acid Amicar, Caprocid 4 C Baclofen Lioresal 4 B Amiodarone 4 B Barbital Veronal 2 A Aminophylline Aminophyllin, etc. 3 B Barbiturates 2 A Aminopyrine 4 B Beclomethasone Propaderm 4 C Bemegride Megimide, Mikedimide 2 A

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Benazepril Lotrel, Lotensin 3 B Buprenorphine Temgesic 2 A Bendroflumethiazide Naturetin 4 B Bupropion Wellbutrin 2 A Benoxaprofen 2 A Buspirone Buspar 2 A Benoxinate Dorsacaine 4 C Butabarbital (Secbutobarbitone) Butacaps, Butasol, etc. 2 A Benperidol Anquil 2 A Butacaine Butyn 4 B Bentazepam Tiadipona 2 A Butalbital (Talbutal) Fiorinal 2 A Benzactizine Deprol, Bronchodiletten 2 A Butamben (butyl aminobenzoate) Butesin 4 C Benzocaine 4 B Butanilicaine Hostacain 2 A Benzoctamine 2 A Butaperazine Repoise 2 A Benzodiazepines 2 A Butoctamide Listomin 2 A Tessalon, Tessalon Perles, Butorphanol Stadol, Torbugesic 3 B Benzonatate 2 A Zonatuss Butoxycaine Stadacain 4 B Benzphetamine Didrex 2 A N-Butylscopolamine 3 B Benzthiazide 4 B Caffeine 2 B Benztropine Cogentin 2 A Calusterone Methosorb 3 B Benzylpiperazine (BZP) 1 A Camazepam Paxor 2 A Bepridil Bepadin 4 B Camphor 4 C Betamethasone Betasone, etc. 4 C Candesartan Atcand 3 B Betaxolol Kerlone 3 B Captodiame Covatine 2 A Bethanechol Urecholine, Duvoid 4 C Captopril Capolen 3 B Bethanidine Esbatal 3 A Carazolol Carbacel, Conducton 3 A Biperiden Akineton 3 A Carbachol Lentin, Doryl 3 B Biriperone 2 A Carbamezapine Tegretol 3 B Bisoprolol Zebeta, Bisobloc, etc. 3 B Carbazochrome 4 C Bitolterol Effectin 3 A Carbidopa + levodopa Sinemet 2 A Bolasterone 3 A Carbinoxamine Clistin 3 B Boldenone Equipoise 3 B Carbromol Mifudorm 2 A Boldione 3 A Carfentanil 1 A Bretylium Bretylol 3 B Carisoprodol Rela, Soma 2 B Brimonidine Alphagan 2 A Carphenazine Proketazine 2 A Bromazepam Lexotan, Lectopam 2 A Carpipramine Prazinil 2 A Bromfenac Duract 3 A Carprofen Rimadyl 4 B Bromhexine Oletor, etc. 4 B Carteolol Cartrol 3 B Bromisovalum Diffucord, etc. 2 A Carticaine (see articaine) Septocaine; Ultracaine, etc. 2 A Bromocriptine Parlodel 2 A Carvedilol Coreg 3 B Bromodiphenhydramine 3 B khat, kat, qat, quat, chat, Bromperidol Bromidol 2 A Cathinone catha, Abyssinian tea, 1 A Brompheniramine Dimetane, Disomer 4 B African tea Brotizolam Brotocol 2 A Celecoxib Celebrex 3 B Budesonide Pulmacort, Rhinocort 4 C Cetirizine Zyrtec 4 B Bufexamac 3 A Chloral betaine Beta-Chlor 2 A Bumetanide Bumex 3 B Chloral hydrate Nactec, Oridrate, etc. 2 A Bupivacaine Marcaine 2 A Chloraldehyde (chloral) 2 A

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Chloralose (Alpha-Chloralose) 2 A Clomipramine Anafranil 2 A Chlordiazepoxide Librium 2 A Clonazepam Klonopin 2 A Chlorhexidol 2 A Clonidine Catapres 3 B Chlormerodrin Neohydrin 4 B Clorazepate Tranxene 2 A Chlormezanone Trancopal 2 A Clormecaine Placacid 4 C Chloroform 2 A Clostebol 3 B Chlorophenesin Maolate 4 C Clothiapine Entermin 2 A Chloroprocaine Nesacaine 2 A Clotiazepam Trecalmo, Rize 2 A Chloroquine Avloclor 4 C Cloxazolam Enadel, Sepazon, Tolestan 2 A Chlorothiazide Diuril 4 B Clozapine Clozaril, Leponex 2 A Chlorpheniramine Chlortriemton, etc. 4 B Cobalt 3 B1 Chlorproethazine Newiplege 2 A a-Cobratoxin 1 A Chlorpromazine Thorazine, Largactil 2 A Cocaine 1 B Chlorprothixene Taractan 2 A Codeine 1 A Chlorthalidone Hydroton 4 B Colchicine 4 B Chlorzoxazone Paraflex 4 B Conorphone 2 A Ciclesonide 4 B Corticaine Ultracain 2 A Cilostazol Pletal 5 C Cortisone Cortone, etc. 4 C Cimeterol 3 A Cromolyn Intel 5 C Cimetidine Tagamet 5 D Crotetamide 2 A Cinchocaine Nupercaine 4 C Cyamemazine Tercian 2 A Citalopram Celex 2 A Cyclandelate Cyclospasmol 3 A Clanobutin 4 B Cyclizine Merazine 4 B Clemastine Tavist 3 B Cyclobarbital Phanodorm 2 A Clenbuterol Ventipulmin 3 B Cyclobenzaprine Flexeril 4 B Clibucaine Batrax 4 C Cyclomethylcaine Surfacaine 4 C Clidinium Quarezan, Clindex, etc. 3 B Cyclothiazide Anhydron, Renazide 4 B Clobazam Urbanyl 2 A Cycrimine Pagitane 3 B Clobetasol Temovate 4 C Cyproheptadine Periactin 4 C Clocapramine 2 A Danazol Danocrine 3 B Clocortolone Cloderm 4 C Dantrolene Dantrium 4 C Clofenamide 4 B Darbepoetin Aranesp 2 A Clomethiazole (Chlormethiazole) 2 A Decamethonium Syncurine 2 A

1 For cobalt concentrations of less than 25 parts per billion (ppb) of blood serum or plasma no penalty is recommended. For concentrations of 25 ppb or greater but less than 50 ppb of blood plasma or serum the recommended penalty is a written warning, the placement of the horse on the Veterinarians List with removal from list only after a blood test confirms that the concentration is below 25 ppb of blood plasma or serum. Testing shall be paid by the owner(s) of the horse. Concentrations of 50 ppb or greater in blood plasma or serum have a recommended “B” penalty.

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Dehydrochloromethyltestosterone 3 B Diprenorphine M50/50 2 A Dembroxol (Dembrexine) Sputolysin 4 C Dipyridamole Persantine 3 B Demoxepam 2 A Dipyrone Novin, Methampyrone 4 C Percortin, DOCA, Disopyramide Norpace 4 B Deoxycorticosterone 4 C Descotone, Dorcostrin Divalproex Depakote 3 A Deracoxib Deremaxx 3 B Dixyrazine Esucos 2 A Dermorphin 1 A Dobutamine Dobutrex 3 B Desipramine Norpromine, Pertofrane 2 A Dopamine Intropin 2 A Desonite Des Owen 4 C Donepezil Aricept 1 A Desoximetasone Topicort 4 C Doxacurium Nuromax 2 A Desoxymethyltestosterone 3 B Doxapram Dopram 2 A Detomidine Dormosedan 3 B Doxazosin 3 A Dexamethasone Azium, etc. 4 C Doxefazepam Doxans 2 A Dextromethorphan 4 B Doxepin Adapin, Sinequan 2 A Dextromoramide Palfium, Narcolo 1 A Doxylamine Decapryn 3 B Dextropropoxyphene Darvon 3 B Dromostanolone Drolban 3 B Dezocine Dalgan 2 A Inapsine, Droleptan, Diamorphine 1 A Droperidol Innovar-Vet (with 2 A Diazepam Valium 2 B Fentanyl) Diazoxide Proglycem 3 B Duloxetine 2 A Dibucaine Nupercainal, Cinchocaine 4 C Dyclonine Dyclone 4 C Dichloralphenazone Febenol, Isocom 2 A Dyphylline 3 B Dichlorphenamide Daramide 4 C Edrophonium Tensilon 3 B Diclofenac Voltaren, Voltarol 4 C Eletripan Relpax 3 A Dicumarol Dicumarol 5 C Eltenac 4 C Diethylpropion Tepanil, etc. 2 A Enalapril (metabolite enaloprilat) Vasotec 3 B Diethylthiambutene Themalon 2 A Enciprazine 2 A Diflorasone Florone, Maxiflor 4 C Endorphins 1 A Diflucortolone Flu-Cortinest, etc. 4 C Enkephalins 1 A Diflunisal 3 B Ephedrine 2 A Digitoxin Crystodigin 4 B Epibatidine 2 A Digoxin Lanoxin 4 B Epinephrine 2 A Dihydrocodeine Parcodin 2 A Ergoloid mesylates (dihydroergocornine mesylate, Dihydroergotamine 4 B 2 A Dilorazepam Briantum 2 A dihydroergocristine mesylate, and Diltiazem Cardizem 4 B dihydroergocryptine mesylate) Dimefline 3 A Ergonovine Ergotrate 4 C Dimethisoquin Quotane 4 B Ergotamine Gynergen, Cafergot, etc. 4 B Dimethylsulfoxide (DMSO) Domoso 4 C Erthrityl tetranitrate Cardilate 3 A Dimethylsulphone (MSM) 5 C Erythropoietin (EPO) Epogen, Procrit, etc. 2 A Diphenadione 5 C Esmolol Brevibloc 3 B Diphenhydramine Benadryl 3 B Esomeprazole Nexium 5 D Diphenoxylate Difenoxin, Lomotil 4 B

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Domnamid, Eurodin, Fluanisone Sedalande 2 A Estazolam 2 A Nuctalon Flucinolone Synalar, etc. 4 C Etamiphylline 3 B Fludiazepam Erispam 2 A Etanercept Enbrel 4 B Fludrocortisone Alforone, etc. 4 C Ethacrynic acid Edecrin 3 B Flufenamic acid 3 B Ethamivan 2 A Flumethasone Flucort, etc. 4 C Ethanol 2 A Flumethiazide Ademol 4 B Ethchlorvynol Placidyl 2 A Flunarizine Sibelium 4 B Ethinamate Valmid 2 A Flunisolide Bronilide, etc. 4 C Ethoheptazine Zactane 4 B Rohypnol, Narcozep, Flunitrazepam 2 A Ethopropazine Parsidol 2 A Darkene, Hypnodorm Ethosuximide Zarontin 3 A Flunixin Banamine 4 C* Ethotoin Peganone 4 B Fluocinolone Synalar 4 C Ethoxzolamide Cardrase, Ethamide 4 C Fluocinonide Licon, Lidex 4 C Ethylaminobenzoate (Benzocaine) Semets, etc. 4 C Fluopromazine Psyquil, Siquil 2 A Ethylestrenol Maxibolin, Organon 3 B Fluoresone Caducid 2 A Ethylisobutrazine Diquel 2 A Fluorometholone FML 4 B Ethylmorphine Dionin 1 A Fluoroprednisolone Predef-2X 4 C Ethylnorepinephrine Bronkephrine 3 A Fluoxetine Prozac 2 A Etidocaine Duranest 2 A Fluoxymesterone Halotestin 3 B Etifoxin Stresam 2 A Flupenthixol Depixol, Fluanxol 2 A Etizolam Depas, Pasaden 2 A Prolixin, Permitil, Fluphenazine 2 A Etodolac Lodine 3 B Anatensol, etc. Etodroxizine Indunox 2 A Flupirtine Katadolone 3 A Etomidate 2 A Fluprednisolone Alphadrol 4 C Etorphine HCl M99 1 A Flurandrenolide Cordran 4 C Famotidine Gaster, etc. 5 D Flurazepam Dalmane 2 A Felbamate Felbatol 3 A Flurbiprofen Froben 3 B Felodipine Plendil 4 B Fluspirilene Imap, Redeptin 2 A Fenarbamate Tymium 2 A Fluticasone Flixonase, Flutide 4 C Fenbufen Cincopal 3 B Flutoprazepam Restas 2 A Fenclozic acid Myalex 2 A Fluvoxamine Dumirox, Faverin, etc. 2 A Fenfluramine Pondimin 2 A Formebolone 3 B Fenoldopam Corlopam 3 B Formoterol Altram 3 B Fenoprofen Nalfon 3 B Fosinopril Monopril 3 A Fenoterol Berotec 3 B Fosphenytoin Cerebyx 3 B Fenspiride Respiride, Respan, etc 3 B Furazabol 3 B Fentanyl Sublimaze 1 A Furosemide Lasix N/A Fentiazac 3 B Gabapentin Neurontin 3 B Fexofenadine Allegra 4 C Galantamine Reminyl 2 A Firocoxib 4 C Gallamine Flaxedil 2 A Flecainide Idalon 4 B Gamma Aminobutryic Acid (GABA) Carolina Gold 3 B Floctafenine Idalon, Idarac 4 B Gepirone 2 A

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Gestrinone 3 A Isoflupredone Predef 4 C Glutethimide Doriden 2 A Isomethadone 2 A Glycopyrrolate Robinul 3 B Isometheptene Octin, Octon 4 B Guaifenesin (glycerol guiacolate) Gecolate 4 C Isopropamide Darbid 4 B Guanadrel Hylorel 3 A Isoproterenol Isoprel 2 A Guanethidine Ismelin 3 A Isosorbide dinitrate Isordil 3 B Guanabenz Wytensin 3 B Isoxicam Maxicam 2 A Halazepam Paxipam 2 A Isoxsuprine Vasodilan 4 C Halcinonide Halog 4 C Isradipine DynaCirc 4 B Halobetasol Ultravate 4 C Kebuzone 3 B Haloperidol Haldol 2 A Ketamine Ketalar, Ketaset, Vetalar 2 B Haloxazolam Somelin 2 A Anxon, Laftram, Solatran, Ketazolam 2 A Hemoglobin glutamers Oxyglobin Hemopure 2 A Loftran Heptaminol Corofundol 3 B Ketoprofen Orudis 4 C* Heroin 1 A Ketorolac Toradol 3 A Hexafluorenium Myalexen 2 A Labetalol Normodyne 3 B Hexobarbital Evipal 2 A Lamotrigine Lamictal 3 A Hexocyclium Tral 4 B Lansoprazole 5 D Hexylcaine Cyclaine 4 C Lenperone Elanone-V 2 A Homatropine Homapin 3 B Letosteine Viscotiol, Visiotal 4 C Homophenazine Pelvichthol 2 A Levamisole 2 B Hydralazine Apresoline 3 B Levobunolol Betagan 3 B Hydrochlorthiazide Hydrodiuril 4 B Levomethorphan 2 A Hydrocodone (dihydrocodienone) Hycodan 1 A Levorphanol Levo-Dremoran 1 A Hydrocortisone (Cortisol) Cortef, etc. 4 C Lidocaine Xylocaine 2 B Hydroflumethiazide Saluron 4 B Lisinopril Prinivil, Zestril 3 A Hydromorphone Dilaudid 1 A Lithium Lithizine, Duralith, etc. 2 A Hydroxyamphetamine Paradrine 1 A Lobeline 2 A 4-Hydroxytestosterone 3 B Lofentanil 1 A Hydroxyzine Atarax 2 B Loflazepate, Ethyl Victan 2 A Ibomal Noctal 2 A Loperamide Imodium 2 A Ibuprofen Motrin, Advil, Nurpin, etc. 4 C Loprazolam Dormonort, Havlane 2 A Ibutilide Corvert 3 B Loratidine Claritin 4 B Iloprost Ventavis 3 A Lorazepam Ativan 2 A Imavate, Presamine, Lormetazepam Noctamid 2 A Imipramine 2 A Tofranil Losartan Hyzaar 3 B Indomethacin Indocin 3 B Loxapine Laxitane 2 A Infliximab Remicade 4 B Mabuterol 3 A Ipratropium 3 B Maprotiline Ludiomil 2 A Irbesarten Avapro 3 A Mazindol Sanorex 1 A Isapirone 2 A Mebutamate Axiten, Dormate, Capla 2 A Isocarboxazid Marplan 2 A Mecamylamine Inversine 3 B Isoetharine Bronkosol 3 B Meclizine Antivert, Bonine 4 B

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Meclofenamic acid Arquel 4 C Methapyrilene Histadyl, etc. 4 B Meclofenoxate Lucidiril, etc. 2 A Methaqualone Quaalude 1 A Medazepam Nobrium, etc. 2 A Metharbital Gemonil 2 A Medetomidine Domitor 3 B Methasterone 3 A Medrysone Medriusar, etc. 4 C Methazolamide Naptazane 4 C Mefenamic acid Ponstel 3 B Methcathinone 1 A Meloxicam Mobic 4 B Methdilazine Tacaryl 4 B Melperone Eunerpan 2 A Methixene Trest 3 A Memantine Namenda 2 A Methocarbamol Robaxin 4 C Meparfynol Oblivon 2 A Methohexital Brevital 2 A Mepazine Pacatal 2 A Methotrexate Folex, Nexate, etc. 4 B Mepenzolate Cantil 3 A Methotrimeprazine Levoprome, Neurocil, etc. 2 A Meperidine Demerol 1 A Methoxamine Vasoxyl 3 A Mephenesin Tolserol 4 B Methoxyphenamine Orthoxide 3 A Mephenoxalone Control, etc. 2 A Methscopolamine Pamine 4 B Mephentermine Wyamine 1 A Methsuximide Celontin 3 A Mephenytoin Mesantoin 2 A Methylatropine 3 B Mephobarbital Methylchlorthiazide Enduron 4 B Mebaral 2 A (Methylphenobarbital) Methyldienolone 3 B Mepivacaine Carbocaine 2 B Methyldopa Aldomet 3 A Meprobamate Equanil, Miltown 2 A Methylhexanamine Geranamine 1 A Meralluride Mercuhydrin 4 B (Methylhexaneamine) Merbaphen Novasural 4 B Methylergonovine Methergine 4 C Mercaptomerin Thiomerin 4 B Methylnortestosterone 3 B Mercumalilin Cumertilin 4 B Methylphenidate Ritalin 1 A Mersalyl Salyrgan 4 B Methylprednisolone Medrol 4 C Mesalamine Asacol 5 C Methyltestosterone Metandren 3 A Mesoridazine Serentil 2 A Methyl-1-testosterone 3 A Mestanolone 3 B Methyprylon Noludar 2 A Mesterolone 3 B Methysergide Sansert 4 B Metaclazepam Talis 2 A Metiamide 4 B Metaproterenol Alupent, Metaprel 3 B Metoclopramide Reglan 4 C Metaraminol Aramine 1 A Metocurine Metubine 2 A Metaxalone Skelaxin 4 B Metolazone 3 B Metazocine 2 A Metomidate Hypnodil 2 A Metenolone 3 B Metopon 1 A Methachloline 3 A (methydihydromorphinone) Methadone Dolophine 1 A Metoprolol Lopressor 3 B Methamphetamine Desoxyn 1 A Mexazolam Melex 2 A Methandienone 3 B Mexilitine Mexilil 4 B Methandriol Probolic 3 B Mibefradil Posicor 3 B Methandrostenolone Dianabol 3 A Mibolerone 3 B Methantheline Banthine 3 B Midazolam Versed 2 A

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Midodrine Pro-Amiline 3 B Nizatidine Axid 5 C Milrinone 4 B 19-Norandrostenediol 3 B Minoxidil Loniten 3 B 19-Norandrostenedione 3 B Mirtazepine Remeron 2 A Norbolethone 3 B Misoprostel Cytotec 5 C Norclostebol 3 B Mivacurium Mivacron 2 A Nordiazepam Calmday, Nordaz, etc. 2 A Modafinil Provigil 2 A Norepinephrine 2 A Moexipril (metabolite, moexiprilat) Uniretic 3 B Norethandrolone 3 A Molindone Moban 2 A Nortestosterone 4 C Mometasone Elocon 4 C Nortriptyline Aventyl, Pamelor 2 A Montelukast Singulair 4 C Nylidrine Arlidin 3 A Moperone Luvatren 2 A Olanzepine Zyprexa 2 A Morphine 1 B Olmesartan Benicar 3 A Mosaprimine 2 A Olsalazine Dipentum 4 B Muscarine 3 A Omeprazole Prilosec, Losec 5 D myo-Inositol Trispyrophosphate (ITPP) 1 A Orphenadrine Norlfex 4 B Anthraxan, Relafen, Oxabolone 3 B Nabumetone 3 A Reliflex Oxandrolone Anavar 3 B Nadol Corgard 3 B Oxaprozin Daypro, Deflam 4 C Naepaine Amylsine 4 C Oxazepam Serax 2 A Nalbuphine Nubain 2 A Oxazolam Serenal 2 A Nalorphine Nalline, Lethidrone 2 A Oxcarbazepine Trileptal 3 A Naloxone Narcan 3 A Oxilofrine (hydroxyephedrine) 2 A Naltrexone Revia 3 A Oxprenolol Trasicor 3 B Nandrolin, Laurabolin, Oxycodone Percodan 1 A Nandrolone 3 B Durabolin Oxymesterone 3 B Naphazoline Privine 4 B Oxymetazoline Afrin 4 B Naproxen Equiproxen, Naprosyn 4 C Oxymetholone Adroyd, Anadrol 3 B Naratriptan Amerge 3 B Oxymorphone Numorphan 1 A Nebivolol 3 A Oxyperitine Forit, Integrin 2 A Nedocromil Tilade 5 C Oxyphenbutazone Tandearil 4 C Nefazodone Serzone 2 A Oxyphencyclimine Daricon 4 B Nefopam 3 A Oxyphenonium Antrenyl 4 B Neostigmine Prostigmine 3 B Paliperidone 2 A Nicardipine Cardine 4 B Pancuronium Pavulon 2 A Nifedipine Procardia 4 B Pantoprazole Protonix 5 D Niflumic acid Nifluril 3 B Papaverine Pavagen, etc. 3 A Nikethamide Coramine 1 A Paraldehyde Paral 2 A Nimesulide 3 B Paramethadione Paradione 3 A Nimetazepam Erimin 2 A Paramethasone Haldrone 4 C Nimodipine Nemotop 4 B Pargyline Eutonyl 3 A Nitrazepam Mogadon 2 A Paroxetine Paxil, Seroxat 2 A Nitroglycerin 3 B Pemoline Cylert 1 A

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Penbutolol Levatol 3 B Pipecuronium Arduan 2 A Penfluridol Cyperon 2 A Pipequaline 2 A Pentaerythritol tetranitrate Duotrate 3 A Piperacetazine Psymod, Quide 2 A Pentazocine Talwin 3 B Piperocaine Metycaine 2 A Pentobarbital Nembutal 2 A Pipotiazine Lonseren, Piportil 2 A Pentoxyfylline Trental, Vazofirin 4 C Pipradrol Dataril, Gerondyl, etc. 2 A Pentylenetetrazol Metrazol, Nioric 1 A Piquindone 2 A Perazine Taxilan 2 A Pirbuterol Maxair 3 A Perfluorodecolin 2 A Pirenzapine Gastrozepin 5 C Perfluorodecahydronophthalene 2 A Piretanide Arelix, Tauliz 3 B Perfluorooctylbromide 2 A Piritramide 1 A Perfluorotripropylamine 2 A Piroxicam Feldene 3 B Perfluorocarbons 2 A Polyethylene glycol 5 C Pergolide Permax 3 B Polythiazide Renese 4 B Periciazine Alodept, etc. 2 A Pramoxine Tronothaine 4 C Perindopril Biprel 3 A Prazepam Verstran, Centrax 2 A Perlapine Hypnodin 2 A Prazosin Minipress 3 B Perphenazine Trilafon 2 A Prednisolone Delta-Cortef, etc. 4 C Phenacemide Phenurone 4 B Prednisone Meticorten, etc. 4 C Phenaglycodol Acalo, Alcamid, etc. 2 A Prilocaine Citanest 2 A Phenazocine Narphen 1 A Primidone Mysoline 3 B Phencyclidine (PCP) Sernylan 1 A Probenecid 4 C Phendimetrazine Bontril, etc. 1 A Procainamide Pronestyl 4 B Phenelzine Nardelzine, Nardil 2 A Procaine 3 B Phenindione Hedulin 5 C Procaterol Pro Air 3 A Phenmetrazine Preludin 1 A Prochlorperazine Darbazine, Compazine 2 A Phenobarbital Luminal 2 A Procyclidine Kemadrin 3 B Phenoxybenzamine Dibenzyline 3 B Promazine Sparine 3 B Phenprocoumon Liquamar 5 C Promethazine Phenergan 3 B Phensuximide Milontin 4 B Propafenone Rythmol 4 B Phentermine Iomamin 2 A Propanidid 2 A Phentolamine Regitine 3 B Propantheline Pro-Banthine 3 A Phenylbutazone Butazolidin 4 C* Proparacaine Ophthaine 4 C Phenylephrine Isophrin, Neo-Synephrine 3 B Propentophylline Karsivan 3 B Phenylpropanolamine Propadrine 3 B Propiomazine Largon 2 A Phenytoin Dilantin 4 B Propionylpromazine Tranvet 2 A Physostigmine Eserine 3 B Propiram 2 A Picrotoxin 1 A Propofol Diprivan, Disoprivan 2 A Piminodine Alvodine, Cimadon 2 A Propoxycaine Ravocaine 2 A Pimozide Orap 2 A Propranolol Inderal 3 B Pinazepam Domar 2 A Propylhexedrine Benzedrex 4 B Pindolol Viskin 3 A Prostanazol 3 B Pipamperone Dipiperon 2 A Prothipendyl Dominal 2 A

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Protokylol Ventaire 3 A Somatrem Protropin 2 A Protriptyline Concordin, Triptil 2 A Sotalol Betapace, Sotacor 3 B Proxibarbital Axeen, Centralgol 2 A Spiclomazine 2 A Pseudoephedrine Cenafed, Novafed 3 B Spiperone 2 A Pyridostigmine Mestinon, Regonol 3 B Spirapril, metabolite Spiraprilat Renomax 3 A Pyrilamine Neoantergan, Equihist 3 B Spironalactone Aldactone 4 B Pyrithyldione Hybersulfan, Sonodor 2 A Stanozolol Winstrol-V 3 B Quazipam Doral 2 A Stenbolone 3 B Quetiapine Seroquel 2 A Strychnine 1 B Quinbolone 3 B Succinylcholine Sucostrin, Quelin, etc. 2 A Quinapril, Quinaprilat Accupril 3 A Sufentanil Sufenta 1 A Quinidine Quinidex, Quinicardine 4 B Sulfasalazine Azulfidine, Azaline 4 C Rabeprazole Aciphex 5 D Sulfondiethylmethane 2 A Racemethorphan 2 A Sulfonmethane 2 A Racemorphan 2 A Sulforidazine Inofal 2 A Raclopride 2 A Sulindac Clinoril 3 A Ractopamine Paylean 2 A Sulpiride Aiglonyl, Sulpitil 2 A Ramipril, metabolite Ramiprilat Altace 3 A Sultopride Barnetil 2 A Ranitidine Zantac 5 D Sumatriptan Imitrex 3 B Remifentanil Ultiva 1 A Synthetic cannabis Spice, K2, Kronic 1 A Remoxipride Roxiam 2 A Tadalasil Cialis 3 A Reserpine Serpasil 2 A Talbutal Lotusate 2 A Rilmazafone 2 A Tandospirone 2 A Risperidone 2 A Telmisartin Micardis 3 B Ritanserin 2 A Temazepam Restoril 2 A Ritodrine Yutopar 3 B Tenoxicam Alganex, etc. 3 B Rivastigmine Exelon 2 A Tepoxalin 3 B Rizatriptan Maxalt 3 B Terazosin Hytrin 3 A Rocuronium Zemuron 2 A Terbutaline Brethine, Bricanyl 3 B Rofecoxib Vioxx 2 A Terfenadine Seldane, Triludan 4 B Romifidine Sedivet 2 B Testolactone Teslac 3 B Ropivacaine Naropin 2 A Testosterone 3 B Salicylamide 4 C Tetrabenazine Nitoman 2 A Salicylate 4 C Tetracaine Pontocaine 2 A Salmeterol 3 B Tetrahydrogestrinone 3 A Scopolamine (Hyoscine) Triptone 3 B Tetrahydrozoline Tyzine 4 B Secobarbital (Quinalbarbitone) Seconal 2 A Tetrazepam Musaril, Myolastin 2 A Selegiline Eldepryl, Jumex, etc. 2 A Thebaine 2 A Sertraline Lustral, Zoloft 2 A Theobromine 4 B Sibutramine Meridia 3 B Theophylline Aqualphyllin, etc. 3 B Sildenafil Viagra 3 A Thialbarbital Kemithal 2 A Snake Venoms 2 A Thiamylal Surital 2 A Somatropin Nutropin 2 A Thiethylperazine Torecan 2 A

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Alphabetical Substance List (Cont) Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Thiopental Pentothal 2 A Trimethaphan Arfonad 3 A Thiopropazate Dartal 2 A Trimipramine Surmontil 2 A Thioproperazine Majeptil 2 A Tripelennamine PBZ 3 B Thioridazine Mellaril 2 A Triprolidine Actidil 4 B Thiosalicylate 4 C Tubocurarine (Curare) Metubin 2 A Thiothixene Navane 2 A Tybamate Benvil, Nospan, etc. 2 A Thiphenamil Trocinate 4 B Urethane 2 A Tiapride Italprid, Luxoben, etc. 2 A Valdecoxib 2 A Tiaprofenic acid Surgam 3 B Valerenic acid 3 A Tiletamine Component of Telazol 2 A Valnoctamide Nirvanyl 2 A Timiperone Tolopelon 2 A Valsartan Diovan 3 B Timolol Blocardrin 3 B Vardenafil Levitra 3 A Tocainide Tonocard 4 B Vedaprofen 4 B Tofisopam Grandaxain, Seriel 2 A Venlafaxine Efflexor 2 A Tolazoline Priscoline 3 B Veralipride Accional, Veralipril 2 A Tolmetin Tolectin 3 B Verapamil Calan, Isoptin 4 B Topirimate Topamax 2 A Vercuronium Norcuron 2 A Torsemide (Torasemide) Demadex 3 A Viloxazine Catatrol, Vivalan, etc. 2 A Tramadol Ultram 2 A Vinbarbital Delvinol 2 A Trandolapril (and metabolite, Vinylbital Optanox, Speda 2 A Tarka 3 B trandolaprilat) Warfarin Coumadin, Coufarin 5 C Tranexamic acid 4 C Xylazine Rompun, Bay Va 1470 3 B Tranylcypromine Parnate 2 A Xylometazoline Otrivin 4 B Trazodone Desyrel 2 A Yohimbine 2 A Trenbolone Finoplix 3 B Zafirlukast Accolate 4 C Tretoquinol Inolin 2 A Zaleplon Sonata 2 A Triamcinolone Vetalog, etc. 4 C Zeranol Ralgro 4 C Triamterene Dyrenium 4 B Ziconotide 1 A Triazolam Halcion 2 A Zileuton Zyflo 4 C Tribromethanol 2 A Zilpaterol hydrochloride Zilpaterol 2 A Tricaine methanesulfonate Finquel 2 A Ziprasidone Geoden 2 A Trichlormethiazide Naqua, Naquasone 4 C Zolazepam 2 A Trichloroethanol 2 A Zolmitriptan Zomig 3 B Tricholoethylene Trilene, Trimar 2 A Zolpidem Ambien, Stilnox 2 A Triclofos Triclos 2 A Zomepirac Zomax 2 A Tridihexethyl Pathilon 4 B Zonisamide Zonegran 3 B Trifluomeprazine Nortran 2 A Zopiclone Imovan 2 A Trifluoperazine Stelazine 2 A Zotepine Lodopin 2 A Trifluperidol Triperidol 2 A Zuclopenthixol Ciatyl, Cesordinol 2 A Triflupromazine Vetame, Vesprin 2 A ∆-1-androstene-3, 17-diol 3 A Trihexylphenidyl Artane 3 A ∆-1-androstene-3, 17-dione 3 A Trimeprazine Temaril 4 B ∆-1-dihydrotestosterone 3 A Trimethadione Tridione 3 B

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Alphabetical Substance List (Cont) Drug Penalty Drug/Substance Trade Name(s) Class Class *See Recommended Penalty Section of Document

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Listing by Classification Class 1: Stimulant and depressant drugs that have the highest potential to affect performance and that have no generally accepted medical use in the racing horse. Many of these agents are Drug Enforcement Agency (DEA) Schedule II substances. These include the following drugs and their metabolites: Opiates, opium derivatives, synthetic opioids, psychoactive drugs, all DEA Schedule 1* substances (see http://www.usdoj.gov/dea/pubs/scheduling.html), amphetamines and amphetamine-like drugs as well as related drugs, including but not limited to apomorphine, nikethamide, mazindol, pemoline, and pentylenetetrazol. Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class 3,4-methylenedioxypyprovalerone MDPV, “Bath Salts” 1 A Mazindol Sanorex 1 A Alfentanil Alfenta 1 A Meperidine Demerol 1 A Aminoxafen, Mephentermine Wyamine 1 A Aminorex Aminoxaphen, Apiquel, 1 A Metaraminol Aramine 1 A McN-742, Menocil Methadone Dolophine 1 A Amphetamine 1 A Methamphetamine Desoxyn 1 A Anileridine Leritine 1 A Methaqualone Quaalude 1 A Apomorphine 1 A Methcathinone 1 A Benzylpiperazine (BZP) 1 A Methylhexanamine Geranamine 1 A Carfentanil 1 A (Methylhexaneamine) khat, kat, qat, quat, chat, Methylphenidate Ritalin 1 A Cathinone catha, Abyssinian tea, 1 A Metopon 1 A African tea (methyldihydromorphinone) a-Cobratoxin 1 A Morphine 1 B Cocaine 1 B Myo-inositol trisphrophosphate 1 A Codeine 1 A (ITPP) DEA Schedule 1 (all)* 1 A Nikethamide Coramine 1 A Dermorphin 1 A Oxycodone Percodan 1 A Dextromoramide Palfium, Narcolo 1 A Oxymorphone Numorphan 1 A Diamorphine 1 A Pemoline Cylert 1 A Donepezil Aricept 1 A Pentylenetetrazol Metrazol, Nioric 1 A Endorphins 1 A Phenazocine Narphen 1 A Enkephalins 1 A Phencyclidine (PCP) Sernylan 1 A Ethylmorphine Dionin 1 A Phendimetrazine Bontril, etc. 1 A Etorphine HCl M99 1 A Phenmetrazine Preludin 1 A Fentanyl Sublimaze 1 A Picrotoxin 1 A Heroin 1 A Piritramide 1 A Hydrocodone (dihydrocodienone) Hydocane 1 A Remifentanil Ultiva 1 A Hydromorphone Dilaudid 1 A Strychnine 1 B Hydroxyamphetamine Paradrine 1 A Sufentanil Sufenta 1 A Levorphanol Levo-Dremoran 1 A Synthetic cannabis Spice, K2, Kronic 1 A Lofentanil 1 A Ziconotide 1 A

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Listing by Classification (Continued) Class 2: Drugs that have a high potential to affect performance, but less of a potential than Class 1. These drugs are 1) not generally accepted as therapeutic agents in racing horses, or 2) they are therapeutic agents that have a high potential for abuse.

Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class 3-Methoxytyramine 3-MT 2 A Brimonidine Alphagan 2 A Acecarbromal 2 A Bromazepam Lexotan, Lectopam 2 A Acetophenazine Tindal 2 A Bromisovalum Diffucord, etc. 2 A Adinazolam 2 A Bromocriptine Parlodel 2 A Alclofenac 2 A Bromperidol Bromidol 2 A Alcuronium Alloferin 2 A Brotizolam Brotocol 2 A Alphaprodine Nisentil 2 A Bupivacaine Marcaine 2 A Alpidem Anaxyl 2 A Buprenorphine Temgesic 2 A Alprazolam Xanax 2 A Buspirone Buspar 2 A Althesin Saffan 2 A Bupropion Wellbutrin 2 A Amisulpride Solian 2 A Butabarbital (Secbutobarbitone) Butacaps, Butasol, etc. 2 A Amitriptyline Elavil, Amitril, Endep 2 A Butalbital (Talbutal) Fiorinal 2 A Amobarbital Amytal 2 A Butanilicaine Hostacain 2 A Amoxapine Asendin 2 A Butaperazine Repoise 2 A Amperozide 2 A Butoctamide Listomin 2 A Anilopam Anisine 2 A Caffeine 2 B Aprobarbital Alurate 2 A Camazepam Paxor 2 A Septocaine; Ultracaine, Captodiame Covatine 2 A Articaine 2 A etc. Carbidopa + levodopa Sinemet 2 A Atomoxetine Strattera 2 A Carbromol Mifudorm 2 A Atracurium Tracrium 2 A Carisoprodol Soma, Rela 2 B Azacylonol Frenque 2 A Carphenazine Proketazine 2 A Stresnil, Suicalm, Fentaz Carpipramine Prazinil 2 A Azaperone 2 A (with Fentanyl) Septocaine; Ultracaine, Carticaine (see articaine) 2 A Barbital Veronal 2 A etc. Barbiturates 2 A Chloralose (Alpha-Chloralose) 2 A Bemegride Megimide, Mikedimide 2 A Chloral betaine Beta-Chlor 2 A Benoxaprofen 2 A Chloral hydrate Nactec, Oridrate, etc. 2 A Benperidol Anquil 2 A Chloraldehyde (chloral) 2 A Bentazepam Tiadipona 2 A Chlordiazepoxide Librium 2 A Benzactizine Deprol, Bronchodiletten 2 A Chlormezanone Trancopal 2 A Benzoctamine 2 A Chloroform 2 A Benzodiazepines 2 A Chlorhexidol 2 A Tessalon, Tessalon Chloroprocaine Nesacaine 2 A Benzonatate 2 A Perles, Zonatuss Chlorproethazine Newiplege 2 A Benzphetamine Didrex 2 A Chlorpromazine Thorazine, Largactil 2 A Benztropine Cogentin 2 A Chlorprothixene Taractan 2 A Biriperone 2 A Citalopram Celex 2 A

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Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Clobazam Urbanyl 2 A Enciprazine 2 A Clocapramine 2 A Ephedrine 2 A Clomethiazole (Chlormethiazole) 2 A Epibatidine 2 A Clomipramine Anafranil 2 A Epinephrine 2 A Clonazepam Klonopin 2 A Ergoloid Mesylates

Clorazepate Tranxene 2 A (dihydroergocornine 2 A Mesylate, dihydroergocristine mesylate Clothiapine Entermin 2 A Hydergine Clotiazepam Trecalmo, Rize 2 A and dihydroergocryptine mesylate) Enadel, Sepazon, Erythropoietin (EPO) Epogen, Procrit, etc. 2 A Cloxazolam 2 A Domnamid, Eurodin, Tolestan Estazolam 2 A Clozapine Clozaril, Leponex 2 A Nuctalon Conorphone 2 A Ethamivan 2 A Corticaine Ultracain 2 A Ethanol 2 A Crotetamide 2 A Ethchlorvynol Placidyl 2 A Cyamemazine Tercian 2 A Ethinamate Valmid 2 A Cyclobarbital Phanodorm 2 A Ethopropazine Parsidol 2 A Darbepoetin Aranesp 2 A Ethylisobutrazine Diquel 2 A Decamethonium Syncurine 2 A Etidocaine Duranest 2 A Demoxepam 2 A Etifoxin Stresam 2 A Desipramine Norpromine, Pertofrane 2 A Etizolam Depas, Pasaden 2 A Dezocine Dalgan® 2 A Etodroxizine Indunox 2 A Diazepam Valium 2 B Etomidate 2 A Dichloralphenazone Febenol, Isocom 2 A Fenarbamate Tymium 2 A Diethylpropion Tepanil, etc. 2 A Fenclozic Acid Cincopal 2 A Diethylthiambutene Themalon 2 A Fenfluramine Pondimin 2 A Dihydrocodeine Parcodin 2 A Fluanisone Sedalande 2 A Dilorazepam Briantum 2 A Fludiazepam Erispam 2 A Diprenorphine M50/50 2 A Rohypnol, Narcozep, Dixyrazine Esucos 2 A Flunitrazepam Darkene, Hypnodorm Dopamine Intropin 2 A Darkene, Hypnodorm 2 A Doxacurium Nuromax 2 A Darkene, Hypnodorm Doxapram Dopram 2 A Darkene Doxefazepam Doxans 2 A Fluopromazine Psyquil, Siquil 2 A Doxepin Adapin, Sinequan 2 A Fluoresone Caducid 2 A Inapsine, Droleptan, Fluoxetine Prozac 2 A Droperidol Innovar-Vet (with 2 A Flupenthixol Depixol, Fluanxol 2 A Prolixin, Permitil, Fentanyl) Fluphenazine 2 A Duloxetine 2 A Anatensol, etc.

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Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Flurazepam Dalmane 2 A Loxapine Laxitane 2 A Fluspirilene Imap, Redeptin 2 A Maprotiline Ludiomil 2 A Flutoprazepam Restas 2 A Mebutamate Axiten, Dormate, Capla 2 A Fluvoxamine Dumirox, Faverin, etc. 2 A Meclofenoxate Lucidiril, etc. 2 A Galantamine Reminyl 2 A Medazepam Nobrium, etc. 2 A Gallamine Flaxedil 2 A Melperone Eunerpan 2 A Gepirone 2 A Memantine Namenda 2 A Glutethimide Doriden 2 A Meparfynol Oblivon 2 A Halazepam Paxipam 2 A Mepazine Pacatal 2 A Haloperidol Haldol 2 A Mephenoxalone Control, etc. 2 A Haloxazolam Somelin 2 A Mephenytoin Mesantoin 2 A Hemoglobin glutamers Oxyglobin, Hemopure 2 A Mephobarbital (Methylphenobarbital) Mebaral 2 A Hexafluorenium Myalexen 2 A Mepivacaine Carbocaine 2 B Hexobarbital Evipal 2 A Meprobamate Equanil, Miltown 2 A Homophenazine Pelvichthol 2 A Mesoridazine Serentil 2 A Hydroxyzine Atarax 2 B Metaclazepam Talis 2 A Ibomal Noctal 2 A Metazocine 2 A Imavate, Presamine, Metharbital Gemonil 2 A Imipramine 2 A Tofranil Methohexital Brevital 2 A Isapirone 2 A Levoprome, Neurocil, Methotrimeprazine 2 A Isocarboxazid Marplan 2 A etc. Isomethadone 2 A Methyprylon Noludar 2 A Isoproterenol Isoprel 2 A Metocurine Metubine 2 A Isoxicam Maxicam 2 A Metomidate Hypnodil 2 A Ketamine Ketalar, Ketaset, Vetalar 2 B Mexazolam Melex 2 A Ketazolam Anxon, Laftram, Midazolam Versed 2 A 2 A Solatran, Loftran Mirtazepine Remeron 2 A Lenperone Elanone-V 2 A Mivacurium Mivacron 2 A Levamisole 2 B Modafinil Provigil 2 A Levomethorphan 2 A Molindone Moban 2 A Lidocaine Xylocaine 2 B Moperone Luvatren 2 A Lithium Lithizine, Duralith, etc. 2 A Mosaprimine 2 A Lobeline 2 A Nalbuphine Nubain 2 A Loflazepate, Ethyl Victan 2 A Nalorphine Nalline, Lethidrone 2 A Loperamide Imodium 2 A Nefazodone Serzone 2 A Loprazolam Dormonort, Havlane 2 A Nimetazepam Erimin 2 A Lorazepam Ativan 2 A Nitrazepam Mogadon 2 A Lormetazepam Noctamid 2 A Nordiazepam Calmday, Nordaz, etc. 2 A

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Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Norepinephrine 2 A Prilocaine Citanest 2 A Nortriptyline Aventyl, Pamelor 2 A Prochlorperazine Darbazine, Compazine 2 A Olanzepine Zyprexa 2 A Propanidid 2 A Oxazepam Serax 2 A Propiomazine Largon 2 A Oxazolam Serenal 2 A Propionylpromazine Tranvet 2 A Oxilofrine (hydroxyephedrine) 2 A Propiram 2 A Oxyperitine Forit, Integrin 2 A Propofol Diprivan, Disoprivan 2 A Paliperidone 2 A Propoxycaine Ravocaine 2 A Pancuronium Pavulon 2 A Prothipendyl Dominal 2 A Paraldehyde Paral 2 A Protriptyline Concordin, Triptil 2 A Paroxetine Paxil, Seroxat 2 A Proxibarbital Axeen, Centralgol 2 A Penfluridol Cyperon 2 A Pyrithyldione Hybersulfan, Sonodor 2 A Pentobarbital Nembutal 2 A Quazipam Doral 2 A Perazine Taxilan 2 A Quetiapine Seroquel 2 A Perfluorodecolin 2 A Racemethorphan 2 A Perfluorodecahydronophthalene 2 A Racemorphan 2 A Perfluorooctylbromide 2 A Raclopride 2 A Perfluorotripropylamine 2 A Ractopamine Paylean 2 A Perfluorocarbons 2 A Remoxipride Roxiam 2 A Periciazine Alodept, etc. 2 A Reserpine Serpasil 2 A Perlapine Hypnodin 2 A Rilmazafone 2 A Perphenazine Trilafon 2 A Risperidone 2 A Phenaglycodol Acalo, Alcamid, etc. 2 A Ritanserin 2 A Phenelzine Nardelzine, Nardil 2 A Rivastigmine Exelon 2 A Phenobarbital Luminal 2 A Rocuronium Zemuron 2 A Phentermine Iomamin 2 A Rofecoxib Vioxx 2 A Piminodine Alvodine, Cimadon 2 A Romifidine Sedivet 2 B Pimozide Orap 2 A Ropivacaine Naropin 2 A Pinazepam Domar 2 A Secobarbital (Quinalbarbitone) Seconal 2 A Pipamperone Dipiperon 2 A Selegiline Eldepryl, Jumex 2 A Pipecuronium Arduan 2 A Sertraline Lustral, Zoloft 2 A Pipequaline 2 A Snake Venoms 2 A Piperacetazine Psymod, Quide 2 A Somatrem Protropin 2 A Piperocaine Metycaine 2 A Somatropin Nutropin 2 A Pipotiazine Lonseren, Piportil 2 A Spiclomazine 2 A Pipradrol Dataril, Gerondyl, etc. 2 A Spiperone 2 A Piquindone 2 A Succinylcholine Sucostrin, Quelin, etc. 2 A Prazepam Verstran, Centrax 2 A Sulfondiethylmethane 2 A

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Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Sulfonmethane 2 A Trimipramine Surmontil 2 A Sulforidazine Inofal 2 A Tubocurarine (Curare) Metubin 2 A Sulpiride Aiglonyl, Sulpitil 2 A Tybamate Benvil, Nospan, etc. 2 A Sultopride Barnetil 2 A Urethane 2 A Talbutal Lotusate 2 A Valdecoxib 2 A Tandospirone 2 A Valnoctamide Nirvanyl 2 A Temazepam Restoril 2 A Venlafaxine Efflexor 2 A Tetrabenazine Nitoman 2 A Veralipride Accional, Veralipril 2 A Tetracaine Pontocaine 2 A Vercuronium Norcuron 2 A Tetrazepam Musaril, Myolastin 2 A Viloxazine Catatrol, Vivalan, etc. 2 A Thebaine 2 A Vinbarbital Delvinol 2 A Thialbarbital Kemithal 2 A Vinylbital Optanox, Speda 2 A Thiamylal Surital 2 A Yohimbine 2 A Thiethylperazine Torecan 2 A Zaleplon Sonata 2 A Thiopental Pentothal 2 A Zilpaterol hydrochloride Zilpaterol 2 A Thiopropazate Dartal 2 A Ziprasidone Geodon 2 A Thioproperazine Majeptil 2 A Zolazepam 2 A Thioridazine Mellaril 2 A Zolpidem Ambien, Stilnox 2 A Thiothixene Navane 2 A Zomepirac Zomax 2 A Tiapride Italprid, Luxoben, etc. 2 A Zopiclone Imovan 2 A Tiletamine Component of Telazol 2 A Zotepine Lodopin 2 A Timiperone Tolopelon 2 A Zuclopenthixol Ciatyl, Cesordinol 2 A Tofisopam Grandaxain, Seriel 2 A Topirimate Topamax 2 A Tramadol Ultram 2 A Tranylcypromine Parnate 2 A Trazodone Desyrel 2 A Tretoquinol Inolin 2 A Triazolam Halcion 2 A Tribromethanol 2 A Tricaine methanesulfonate Finquel 2 A Trichloroethanol 2 A Tricholoethylene Trilene, Trimar 2 A Triclofos Triclos 2 A Trifluomeprazine Nortran 2 A Trifluoperazine Stelazine 2 A Trifluperidol Triperidol 2 A Triflupromazine Vetame, Vesprin 2 A

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Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Acebutolol Sectral 3 B Bumetanide Bumex 3 B Atrovet, Notensil, Butorphanol Stadol, Torbugesic 3 B Acepromazine 3 B PromAce® N-Butylscopolamine 3 B Albuterol (Salbutamol) Proventil, Ventolin 3 B Calusterone 3 B Almotriptan Axert 3 A Candesartan Atacand 3 B Alprenolol 3 A Captopril Capolen 3 B Ambenonium Mytelase, Myeuran 3 B Carazolol Carbacel, Conducton 3 A Aminophylline Aminophyllin, etc. 3 B Carbachol Lentin, Doryl 3 B Amitraz Mitaban 3 A Carbamezapine Tegretol 3 B Amlodipine Norvasc 3 B Carbinoxamine Clistin 3 B Amyl nitrite 3 A Carteolol Cartrol 3 B Arecoline 3 A Carvedilol Coreg 3 B Arformoterol 3 A Celecoxib Celebrex 3 B Atenolol Tenormin 3 B Cimeterol 3 A Atropine 3 B Clemastine Tavist 3 B Benazepril Lotrel, Lotensin 3 B Clenbuterol Ventipulmin 3 B Betaxolol Kerlone 3 B Clidinium Quarezan, Clindex, etc. 3 B Bethanidine Esbatal 3 A Clonidine Catapres 3 B Biperiden Akineton 3 A Clostebol 3 B Bisoprolol Zebeta, Bisobloc, etc. 3 B Cobalt 3 B2 Bitolterol Effectin 3 A Cyclandelate Cyclospasmol 3 A Bolasterone 3 A Cycrimine Pagitane 3 B Boldenone Equipoise 3 B Danazol Danocrine 3 B Boldione 3 A Dehydrochloromethyltestosterone 3 B Bretylium Bretylol 3 B Deracoxib Deremaxx 3 B Bromfenac Duract 3 A Desoxymethyltestosterone 3 B Bromodiphenhydramine 3 B Detomidine Dormosedan 3 B Bufexamac 3 A Dextropropoxyphene Darvon 3 B

2 For cobalt concentrations of less than 25 parts per billion (ppb) of blood serum or plasma no penalty is recommended. For concentrations of 25 ppb or greater but less than 50 ppb of blood plasma or serum the recommended penalty is a written warning, the placement of the horse on the Veterinarians List with removal from list only after a blood test confirms that the concentration is below 25 ppb of blood plasma or serum. Testing shall be paid by the owner(s) of the horse. Concentrations of 50 ppb or greater in blood plasma or serum have a recommended “B” penalty.

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Listing by Classification (Continued) Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology of which suggests less potential to affect performance than drugs in Class 2. Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Diazoxide Proglycem 3 B Gamma Aminobutryic Acid (GABA) Carolina Gold 3 B Diflunisal 3 B Gestrinone 3 A Dimefline 3 A Glycopyrrolate Robinul 3 B Diphenhydramine Benadryl 3 B Guanadrel Hylorel 3 A Dipyridamole Persantine 3 B Guanethidine Ismelin 3 A Divalproex Depakote 3 A Guanabenz Wytensin 3 B Dobutamine Dobutrex 3 B Heptaminol Corofundol 3 B Doxazosin 3 A Homatropine Homapin 3 B Doxylamine Decapryn 3 B Hydralazine Apresoline 3 B Dromostanolone Drolban 3 B 4-Hydroxytestosterone 3 B Dyphylline 3 B Ibutilide Corvert 3 B Edrophonium Tensilon 3 B Iloprost Ventavis 3 A Eletripan Relpax 3 A Indomethacin Indocin 3 B Enalapril (metabolite enaloprilat) Vasotec 3 B Ipratropium 3 B Erthrityl tetranitrate Cardilate 3 A Irbesarten Avapro 3 A Esmolol Brevibloc 3 B Isoetharine Bronkosol 3 B Etamiphylline 3 B Isosorbide dinitrate Isordil 3 B Ethacrynic acid Edecrin 3 B Kebuzone 3 B Ethosuximide Zarontin 3 A Ketorolac Toradol 3 A Ethylestrenol Maxibolin, Organon 3 B Labetalol Normodyne 3 B Ethylnorepinephrine Bronkephrine 3 A Lamotrigine Lamictal 3 A Etodolac Lodine 3 B Levobunolol Betagan 3 B Felbamate Felbatol 3 A Lisinopril Prinivil, Zestril 3 A Fenbufen Cincopal 3 B Losartan Hyzaar 3 B Fenoldopam Corlopam 3 B Mabuterol 3 A Fenoprofen Nalfon 3 B Mecamylamine Inversine 3 B Fenoterol Berotec 3 B Medetomidine Domitor 3 B Fenspiride Respiride, Respan, etc 3 B Mefenamic Acid Ponstel 3 B Fentiazac 3 B Mepenzolate Cantil 3 A Flurbiprofen Froben 3 B Mestanolone 3 B Flufenamic Acid 3 B Mesterolone 3 B Fluoxymesterone Halotestin 3 B Metaproterenol Alupent, Metaprel 3 B Flupirtine Katadolone 3 A Metenolone 3 B Formebolone 3 B Methachloline 3 A Formoterol Altram 3 B Methandienone 3 B Fosinopril Monopril 3 A Methandriol Probolic 3 B Fosphenytoin Cerebyx 3 B Methandrostenolone Dianabol 3 A Furazabol 3 B Methantheline Banthine 3 B Gabapentin Neurontin 3 B Methasterone 3 A

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Listing by Classification (Continued) Class 3: Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacology of which suggests less potential to affect performance than drugs in Class 2. Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Methixene Trest 3 A Oxabolone 3 B Methoxamine Vasoxyl 3 A Oxandrolone Anavar 3 B Methoxyphenamine Orthoxide 3 A Oxcarbazepine Trileptal 3 A Methsuximide Celontin 3 A Oxprenolol Trasicor 3 B Methylatropine 3 B Oxymesterone 3 B Methyldienolone 3 B Oxymetholone Adroyd, Anadrol 3 B Methyldopa Aldomet 3 A Papaverine Pavagen, etc. 3 A Methylnortestosterone 3 B Paramethadione Paradione 3 A Methyltestosterone Metandren 3 A Pargyline Eutonyl 3 A Methyl-1-testosterone 3 A Penbutolol Levatol 3 B Metolazone 3 B Pentaerythritol tetranitrate Duotrate 3 A Metoprolol Lopressor 3 B Pentazocine Talwin 3 B Mibefradil Posicor 3 B Pergolide Permax 3 B Mibolerone 3 B Perindopril Biprel 3 A Midodrine Pro-Amiline 3 B Phenoxybenzamine Dibenzyline 3 B Minoxidil Loniten 3 B Phentolamine Regitine 3 B Moexipril (metabolite, moexiprilat) Uniretic 3 B Phenylephrine Isophrin, Neo-Synephrine 3 B Muscarine 3 A Phenylpropanolamine Propadrine 3 B Anthraxan, Relafen, Physostigmine Eserine 3 B Nabumetone 3 A Reliflex Pindolol Viskin 3 A Nadol Corgard 3 B Pirbuterol Maxair 3 A Naloxone Narcan 3 A Piretanide Arelix, Tauliz 3 B Naltrexone Revia 3 A Piroxicam Feldene 3 B Nandrolin, Laurabolin, Prazosin Minipress 3 B Nandrolone 3 B Durabolin Primidone Mysoline 3 B Naratriptan Amerge 3 B Procaine 3 B Nebivolol 3 A Procaterol Pro Air 3 A Nefopam 3 A Procyclidine Kemadrin 3 B Neostigmine Prostigmine 3 B Promazine Sparine 3 B Niflumic Acid Nifluril 3 B Promethazine Phenergan 3 B Nimesulide 3 B Propantheline Pro-Banthine 3 A Nitroglycerin 3 B Propentophylline Karsivan 3 B 19-Norandrostenediol 3 B Propranolol Inderal 3 B 19-Norandrostenedione 3 B Prostanazol 3 B Norbolethone 3 B Protokylol Ventaire 3 A Norclostebol 3 B Pseudoephedrine Cenafed, Novafed 3 B Norethandrolone 3 A Pyridostigmine Mestinon, Regonol 3 B Nylidrine Arlidin 3 A Pyrilamine Neoantergan, Equihist 3 B Olmesartan Benicar 3 A Quinapril, Quinaprilat Accupril 3 A

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Listing by Classification (Continued) Class 4: This class includes therapeutic medications that would be expected to have less potential to affect performance than those in Class 3. Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class 2-Aminoheptane Tuamine 4 B Cetirizine Zyrtec 4 B Acetaminophen (Paracetamol) Tylenol, Tempra, etc. 4 C Chlormerodrin Neohydrin 4 B Acetanilid 4 B Chlorophenesin Maolate 4 C Acetazolamide Diamox, Vetamox 4 B Chloroquine Avloclor 4 C Acetophenetidin (Phenacetin) 4 B Chlorothiazide Diuril 4 B Acetylsalicylic acid (Aspirin) 4 C Chlorpheniramine Chlortriemton, etc. 4 B Alclomethasone Aclovate 4 C Chlorthalidone Hydroton 4 B Adrenochrome monosemicarbazone Chlorzoxazone Paraflex 4 B 4 B salicylate Ciclesonide 4 B Aldosterone Aldocortin, Electrocortin 4 B Cinchocaine Nupercaine 4 C Ambroxol Ambril, etc. 4 C Clanobutin 4 B Amcinonide Cyclocort 4 C Clibucaine Batrax 4 C Amiloride Moduretic; Midamor 4 B Clobetasol Temovate 4 C Aminocaproic acid Amicar, Caprocid 4 C Clocortolone Cloderm 4 C Amiodarone 4 B Clofenamide 4 B Aminopyrine 4 B Clormecaine Placacid 4 C Amisometradine Rolictron 4 B Colchicine 4 B Amlopidine Norvasc, Ammivin 4 B Cortisone Cortone, etc. 4 C Amrinone 4 B Cyclizine Merazine 4 B Anisotropine Valpin 4 B Cyclobenzaprine Flexeril 4 B Antipyrine 4 B Cyclomethylcaine Surfacaine 4 C Apazone (Azapropazone) Rheumox 4 B Cyclothiazide Anhydron, Renazide 4 B Aprindine 4 B Cyproheptadine Periactin 4 C Baclofen Lioresal 4 B Dantrolene Dantrium 4 C Beclomethasone Propaderm 4 C Dembroxol (Dembrexine) Sputolysin 4 C Bendroflumethiazide Naturetin 4 B Percortin, DOCA, Deoxycorticosterone 4 C Benoxinate Dorsacaine 4 C Descotone, Dorcostrin Benzocaine 4 B Desonite Des Owen 4 C Benzthiazide 4 B Desoximetasone Topicort 4 C Bepridil Bepadin 4 B Dexamethasone Azium, etc. 4 C Betamethasone Betasone, etc. 4 C Dextromethorphan 4 B Bethanechol Urecholine, Duvoid 4 C Dibucaine Nupercainal, Cinchocaine 4 C Bromhexine Oletor, etc. 4 B Dichlorphenamide Daramide 4 C Brompheniramine Dimetane, Disomer 4 B Diclofenac Voltaren, Voltarol 4 C Budesonide Pulmacort, Rhinocort 4 C Diflorasone Florone, Maxiflor 4 C Butacaine Butyn 4 B Diflucortolone Flu-Cortinest, etc. 4 C Butamben (butyl aminobenzoate) Butesin 4 C Digitoxin Crystodigin 4 B Butoxycaine Stadacain 4 B Digoxin Lanoxin 4 B Camphor 4 C Dihydroergotamine 4 B Carbazochrome 4 C Diltiazem Cardizem 4 B Carprofen Rimadyl 4 B Dimethisoquin Quotane 4 B

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Listing by Classification (Continued) Class 4: This class includes therapeutic medications that would be expected to have less potential to affect performance than those in Class 3. Drug Penalty Drug Penalty Drug/Substance Trade Name(s) Drug/Substance Trade Name(s) Class Class Class Class Dimethylsulfoxide (DMSO) Domoso 4 C Motrin, Advil, Nurpin, Ibuprofen 4 C Diphenoxylate Difenoxin, Lomotil 4 B etc. Dipyrone Novin, Methampyrone 4 C Infliximab Remicade 4 B Disopyramide Norpace 4 B Isoflupredone Predef 4 C Dyclonine Dyclone 4 C Isometheptene Octin, Octon 4 B Eltenac 4 C Isopropamide Darbid 4 B Ergonovine Ergotrate 4 C Isoxsuprine Vasodilan 4 C Ergotamine Gynergen, Cafergot, etc. 4 B Isradipine DynaCirc 4 B Etanercept Enbrel 4 B Ketoprofen Orudis 4 C* Ethoheptazine Zactane 4 B Letosteine Viscotiol, Visiotal 4 C Ethotoin Peganone 4 B Loratidine Claritin 4 B Ethoxzolamide Cardrase, Ethamide 4 C Meclizine Antivert, Bonine 4 B Ethylaminobenzoate (Benzocaine) Semets, etc. 4 C Meclofenamic acid Arquel 4 C Felodipine Plendil 4 B Medrysone Medriusar, etc. 4 C Fexofenadine Allegra 4 C Meloxicam Mobic 4 B Firocoxib 4 C Mephenesin Tolserol 4 B Flecainide Idalon 4 B Meralluride Mercuhydrin 4 B Floctafenine Idalon, Idarac 4 B Merbaphen Novasural 4 B Flucinolone Synalar, etc. 4 C Mercaptomerin Thiomerin 4 B Fludrocortisone Alforone, etc. 4 C Mercumalilin Cumertilin 4 B Flumethasone Flucort, etc. 4 C Mersalyl Salyrgan 4 B Flumethiazide Ademol 4 B Metaxalone Skelaxin 4 B Flunarizine Sibelium 4 B Methapyrilene Histadyl, etc. 4 B Flunisolide Bronilide, etc. 4 C Methazolamide Naptazane 4 C Flunixin Banamine 4 C* Methdilazine Tacaryl 4 B Fluocinolone Synalar 4 C Methocarbamol Robaxin 4 C Fluocinonide Licon, Lidex 4 C Methotrexate Folex, Nexate, etc. 4 B Fluorometholone FML 4 B Methscopolamine Pamine 4 B Fluoroprednisolone Predef-2X 4 C Methylchlorthiazide Enduron 4 B Fluprednisolone Alphadrol 4 C Methylergonovine Methergine 4 C Flurandrenolide Cordran 4 C Methylprednisolone Medrol 4 C Fluticasone Flixonase, Flutide 4 C Methysergide Sansert 4 B Guaifenesin (glycerol guiacolate) Gecolate 4 C Metiamide 4 B Halcinonide Halog 4 C Metoclopramide Reglan 4 C Halobetasol Ultravate 4 C Mexilitine Mexilil 4 B Hexocyclium Tral 4 B Milrinone 4 B Hexylcaine Cyclaine 4 C Mometasone Elocon 4 C Hydrochlorthiazide Hydrodiuril 4 B Montelukast Singulair 4 C Hydrocortisone (Cortisol) Cortef, etc. 4 C Naepaine Amylsine 4 C Hydroflumethiazide Saluron 4 B Naphazoline Privine 4 B Naproxen Equiproxen, Naprosyn 4 C

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Listing by Classification (Continued) Class 5: This class includes those therapeutic medications for which concentration limits have been established by the racing jurisdictions as well as certain miscellaneous agents and other medications as determined by the regulatory bodies. Drug Penalty Drug/Substance Trade Name(s) Class Class Acenocoumarol 5 C Anisindione 5 C Cilostazol Pletal 5 C Cimetidine Tagamet 5 D Cromolyn Intel 5 C Dicumarol Dicumarol 5 C Dimethylsulphone (MSM) 5 C Diphenadione 5 C Esomeprazole Nexium 5 D Famotidine Gaster, etc. 5 D Lansoprazole 5 D Mesalamine Asacol 5 C Misoprostel Cytotec 5 C Nedocromil Tilade 5 C Nizatidine Axid 5 C Omeprazole Prilosec, Losec 5 D Pantoprazole Protonix 5 D Phenindione Hedulin 5 C Phenprocoumon Liquamar 5 C Pirenzapine Gastrozepin 5 C Polyethylene glycol 5 C Rabeprazole Aciphex 5 D Ranitidine Zantac 5 D Warfarin Coumadin, Coufarin 5 C

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Substances that are considered to have no effect on the physiology of a racing animal except to improve nutrition or treat or prevent infections or parasite infestations, are not classified. These Substances normally include antimicrobials, antiparasitic drugs, and nutrients such as vitamins. Examples of such substances include the following:

Sulfonamides and trimethoprim Bufotenine 1. Note: Bufotenine is not commerically available in any form.

Antibiotics: Penicillins 2. Note: Bufotenine is a metabolite of5-methoxy-N-N Cephalosporins dimethyltryptamine, found in reed canary grass Chloramphenicol (and potentially other food source plants). It may Aminoglycosides be found Tetractckubes in the urine of horses eating this grass (and Nitrofurans potentially other plant foods), and has been Metronidazole reported as a positive finding. Findings of bufotenine in equine urine should not be considered for regulatory action. Anthelmintics: Avermectins Benzimadaziles Piperazines Pyrantel Antifungals Vitamins A,D,E,K,B vitamins Vitamin C

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Recommended Penalty and Model Rule

The following are recommended penalties for violations due to the presence of a drug carrying a Category “A” penalty and for violations of ARCI-011-015 and ARCI-025-015: Prohibited Practices:

LICENSED TRAINER: 1st Offense 2nd LIFETIME offense in any jurisdiction 3rd LIFETIME offense in any jurisdiction  Minimum one-year suspension absent mitigating  Minimum three-year suspension absent mitigating  Minimum five-year suspension absent mitigating circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors could be used to impose a maximum of a three-year could be used to impose a maximum of license could be used to impose a maximum of license suspension revocation with no reapplication for a three-year revocation with no reapplication for a five-year period. period.

AND AND AND  Minimum fine of $10,000 or 10% of total purse  Minimum fine of $25,000 or 25% of total purse  Minimum fine of $50,000 or 50% of total purse (greater of the two) absent mitigating circumstances. (greater of the two) absent mitigating circumstances. (greater of the two) absent mitigating circumstances. The presence of aggravating factors could be used The presence of aggravating factors could be used to The preence of aggravating factors could be used to to impose a maximum of $25,000 or 25% of purse impose a maximum of $50,000 or 50% purse impose a maximum of $100,000 or 100% purse (greater of the two). (greater of the two). (greater of the two).

AND AND AND  May be referred to the Commission for any further  May be referred to the Commission for any further  May be referred to the Commission for any further action deemed necessary by the Commission. action deemed necessary by the Commission. action deemed necessary by the Commission. LICENSED OWNER: nd rd st 2 LIFETIME offense in owner’s stable any 3 LIFETIME offense in owner’s stable in any 1 Offense jurisdiction jurisdiction  Disqualification and loss of purse  Disqualification and loss of purse  Disqualification, loss of purse and $50,000 fine AND AND AND  Horse shall be placed on the Veterinarian’s List for  Horse shall be placed on the Veterinarian’s List for  Horse shall be placed on the Veterinarian’s List for 90 days and must pass a commission-approved 120 days and must pass a commission-approved 180 days and must pass a commission-approved examination before becoming eligible to be entered. examination before becoming eligible to be entered. examination before becoming eligible to be entered. AND  Referral to the Commission with a recommendation of a suspension for a minimum of 90 days.

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Recommended Penalty and Model Rule (Continued)

The following are recommended penalties for violations due to the presence of a drug carrying Category “B” penalty, for the presence of more than one NSAID in a plasma/serum sample, subject to the provisions set forth in ARCI-011-020(E) and ARCI-025-020(E) and for violations of the established levels for total carbon dioxide:

LICENSED TRAINER: 1st Offense 2nd offense (365-day period) in any jurisdiction 3rd offense (365-day period) in any jurisdiction  Minimum 15-day suspension absent mitigating  Minimum 30-day suspension absent mitigating  Minimum 60-day suspension absent mitigating circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors could be used to impose a maximum of a 60-day could be used to impose a maximum of a 180-day could be used to impose a maximum of a one-year suspension suspension suspension.

AND AND  Minimum fine of $500 absent mitigating  Minimum fine of $1,000 absent mitigating  Minimum fine of $2,500 absent mitigating circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors could be used to impose a maximum fine of $1,000. could be used to impose a maximum fine of $2,500. could be used to impose a maximum of $5,000 or 5% purse (greater of the two).

AND  May be referred to the Commission for any further action deemed necessary by the Commission. LICENSED OWNER: nd rd st 2 offense (365-day period) in owner’s stable any 3 offense (365-day period) in owner’s stable in any 1 Offense jurisdiction jurisdiction  Disqualification and loss of purse [in the absence of  Disqualification and loss of purse [in the absence of  Disqualification, loss of purse, and in the absence of mitigating circumstances]* mitigating circumstances]* mitigating circumstances a $5,000 fine.* AND AND AND  Horse must pass a commission-approved  Horse must pass a commission-approved  Horse shall be placed on the Veterinarian’s List for examination before becoming eligible to be entered. examination before becoming eligible to be entered. 45 days and must pass a commission-approved examination before becoming eligible to be entered.

*The RMTC recommendation called for loss of purse to happen in absence of mitigating circumstances. The Joint Model Rules Committee has made loss of purse mandatory in their proposal.

Association of Racing Commissioners International, Inc. Page 29 Uniform Classification Guidelines for Foreign Substances

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Recommended Penalty and Model Rule (Continued)

The following are recommended penalties for violations due to the presence of a drug carrying a Category “C” penalty and overages for permitted NSAIDs and furosemide: (All concentrations are for measurements in serum or plasma.)

Phenylbutazone (>2.0-5.0 mcg/ml)* Phenylbutazone (>5.0 mcg/ml) Flunixin (>20 - 100 ng/ml) Flunxin (>100 ng/ml) LICENSED TRAINER Ketoprofen (>2- 50 ng/ml) Ketoprofen (>50 ng/ml) and Furosemide (>100 ng/ml) and/or CLASS C Violations no furosemide when identified as administered 1st Offense (365-day period) in any Minimum of a written warning to maximum fine of Minimum fine of $1,000 absent mitigating circumstances jurisdiction $500

2nd Offense (365-day period) in any Minimum of a written warning to maximum fine of Minimum fine of $1,500 and 15-day suspension absent mitigating jurisdiction $750 circumstances

3rd Offense (365-day period) in any Minimum fine of $500 to a maximum fine of $1,000 Minimum fine of $2,500 and 30-day suspension absent mitigating jurisdiction circumstances

Phenylbutazone (>2.0-5.0 mcg/ml)* Phenylbutazone (>5.0 mcg/ml) Flunixin (>20 - 100 ng/ml) Flunxin (>100 ng/ml) LICENSED OWNER Ketoprofen (>2- 50 ng/ml) Ketoprofen (>50 ng/ml) and Furosemide (>100 ng/ml) and/or CLASS C Violations no furosemide when identified as administered 1st Offense (365-day period) in any Horse may be required to pass commission-approved Loss of purse. Horse must pass commission-approved examination jurisdiction examination before being eligible to run before being eligible to run

2nd Offense (365-day period) in any Horse may be required to pass commission-approved Loss of purse. If same horse, placed on veterinarian’s list for 45 jurisdiction examination before being eligible to run days, must pass commission-approved examination before being eligible to run

3rd Offense (365-day period) in any Disqualification and loss of purse. Horse must pass Loss of purse. Minimum $5,000 fine. If same horse, placed on jurisdiction commission-approved examination before being eligible veterinarian’s list for 60 days, must pass commission-approved to run examination before being eligible to run

*If the trainer has not had more than one violation within the previous two years, the Stewards/Judges are encouraged to issue a warning in lieu of a fine provided the reported level is below 3.0 mcg/ml absent of aggravating factors.

After a two-year period, if the licensee has had no further violations, any penalty due to an overage in the 2.0-5.0 category will be expunged from the licensee’s record for penalty purposes.

Association of Racing Commissioners International, Inc. Page 30 Uniform Classification Guidelines for Foreign Substances

Version 11.00 - Revised December 2015

Recommended Penalty and Model Rule (Continued)

The recommended penalty for a violation involving a drug that carries a Category “D” penalty is a written warning to the trainer and owner. Multiple violations may result in fines and/or suspension.

Association of Racing Commissioners International, Inc. Page 31 Uniform Classification Guidelines for Foreign Substances

Version 11.00 - Revised December 2015

Recent Document Revisions Approx. Version Date Drug/Substance Notes Page(s) Corrected typographical error to reflect Class 4, Penalty B 11.00 December 2015 2-Aminoheptane 1, 23 Substance Corrected typographical error to reflect Class 4, Penalty B 11.00 December 2015 Xylometazoline 11, 25 Substance Corrected typographical error to reflect Class 2, Penalty A 11.00 December 2015 Rivastigmine 10, 17 Substance Corrected typographical error to reflect Class 5, Penalty D 11.00 December 2015 Rabeprazole 10 26 Substance Corrected typographical error to reflect Class 2, Penalty A 11.00 December 2015 Prilocaine 9, 17 Substance Corrected typographical error to reflect Class 4, Penalty B 11.00 December 2015 Hexocyclium 6, 24 Substance Corrected typographical error to reflect Class 3, Penalty B 11.00 December 2015 Gabapentin 5, 20 Substance Corrected typographical error to reflect Class 2, Penalty A 11.00 December 2015 Ergoloid Mesylates 4, 15 Substance Corrected typographical error to reflect Class 4, Penalty B 11.00 December 2015 Butacaine 2, 23 Substance Corrected typographical error to reflect Class 4, Penalty C 11.00 December 2015 Budesonide 2, 23 Substance Corrected typographical error to reflect Class 2, Penalty A 11.00 December 2015 Brimonidine 2, 14 Substance Corrected typographical error to reflect Class 3, Penalty B 11.00 December 2015 Benazepril 2, 19 Substance Corrected typographical error to reflect Class 3, Penalty B 11.00 December 2015 Amlodipine 1, 19 Substance 11.00 December 2015 3-Methoxytyramine Added as Class 2, Penalty A Substance 1, 14 10.00 July 2015 Methylhexanamine Added alternative spelling 7, 13

Association of Racing Commissioners International, Inc. Page 32 Uniform Classification Guidelines for Foreign Substances

Version 11.00 - Revised December 2015

Approx. Version Date Drug/Substance Notes Page(s) Gamma Aminobutryic Acid 10.00 July 2015 Added as Class 3, Penalty B Substance 5, 19 (GABA) Added as Class 3, Penalty B with note to refer to ARCI Endogenous, Dietary, or Environmental Substances Schedule for 9.00 April 2015 Cobalt 3, 18 threshold and penalty information for contrations of less than 50 parts per billion (ppb) in blood serum or plasma Changed Penalty Class from “B” to “C” to conform to the ARCI 8.00 December 2014 Firocoxib 5, 23 Controlled Therapeutic Medication Schedule Had been previously omitted from Listing by Classification Section, 8.00 December 2014 Acenocoumarol 25 Added to section 8.00 December 2014 Deracoxib Corrected Spelling in Alphabetical Listing by Substance Section 3 8.00 December 2014 Norclostebol Corrected Spelling in Alphabetical Listing by Substance Section 8 8.00 December 2014 Rizatriptan Corrected Spelling in Alphabetical Listing by Substance Section 10 8.00 December 2014 Dehydrochloromethyltestosterone Corrected Spelling in Alphabetical Listing by Substance Section 3 8.00 December 2014 Amiodarone Corrected Spelling in Listing by Classification Section 22 8.00 December 2014 2-Aminoheptane Corrected Spelling in Listing by Classification Section 22 8.00 December 2014 Bupropion Corrected Spelling in Listing by Classification Section 13 8.00 December 2014 Alclofenac Assigned Penalty Class A 1, 13 Updated the recommended penalty for Ketoprofen to comply with Recommended Penalties for 8.00 December 2014 the primary threshold established in the ARCI Controlled 29 Ketoprofen Therapeutic Medication Schedule. Corrected typographical error on recommended penalties for Class B substances for licensed owners. Version 7.00 incorrectly 8.00 December 2014 Class B Recommended Penalties recommended penalties for second or third offense in the owner’s 28 lifetime. Version 8.00 corrects error and recommends penalty for second or third offense in 365-day period. Addition is not a change ot the Uniform Classification Guidelines. Aminorex has been a DEA Schedule 1 substance. All DEA Schedule 8.00 December 2014 Aminorex 1, 13 1 substances are considered Class 1, Penalty A substances by reference. By request, Aminorex has been listed to avoid confusion. 8.00 December 2014 Bufotenine Corrected the precursor to 5-methoxy-N-N dimethyltryptamine 26

Association of Racing Commissioners International, Inc. Page 33 Uniform Classification Guidelines for Foreign Substances

Version 11.00 - Revised December 2015

Approx. Version Date Drug/Substance Notes Page(s) 7.00 January 2014 Pergolide Added as Class 3, Penalty B 8, 20 6.00 December 2013 Methylhexaneamine Added as Class 1, Penalty A 7, 12 Moved from Class 3 to Class 2 Substance, Penalty Remains 5.00 December 2012 Zilpaterol hydrochloride 11, 17 Unchanged 5.00 December 2012 Tetramisole hydrochloride Removed from Non-Classified Substance list 26 5.00 December 2012 Ambroxol Moved from Class 4, Penalty B to Class 4, Penalty C 1, 22 Corrected typographical error in Drug Class (Incorrectly listed as a 4.01 October 2012 Ractopamine 9, 16 Class 3 substance) Corrected typographical error on Penalty Class (Listed as Penalty 4.01 October 2012 Pyrilamine 9, 20 Class A in “Listing by Classification” section. myo-inositol trispyrophosphate 4.00 July 2012 Added as Class 1, Penalty A 7, 12 (ITPP) 4.00 July 2012 Benzonatate Added as Class 2, Penalty A 2, 13 Corrected Penalty Class omission in Alphabetical Listing section of 3.00 December 2011 Almotriptan 1, 18 document Corrected Penalty Class omission in Alphabetical Listing section of 3.00 December 2011 Naltrexone 7, 20 document Corrected Penalty Class omission in Alphabetical Listing section of 3.00 December 2011 Amiloride 1, 22 document Corrected Penalty Class omission in Alphabetical Listing section of 3.00 December 2011 Butanilicaine 2, 13 document 3.00 December 2011 3,4-methylenedioxy-pyrovalerone, Corrected typographical error in Trade Name sections 1, 12 aka MDPV, “Bath Salts”

3.00 December 2011 Carbazochrome Added as Class 4, Penalty C 2, 22

Edited Drug Classification definitions to remove mention of DMSO 2.01 August 2011 Dimethylsulfoxide (DMSO) vii from Class 5 definition Language pertaining to all drugs/substances not found in this 2.00 July 2011 > ii document shall be considered a Class I, Penalty A Substance

Association of Racing Commissioners International, Inc. Page 34 Uniform Classification Guidelines for Foreign Substances

Version 11.00 - Revised December 2015

Approx. Version Date Drug/Substance Notes Page(s) Penalties for tests over 2.0 micrograms per milliliter of plasma or 2.00 July 2011 Phenylbutazone serum but less than 5.0 micrograms per milliliter of plasma or serum 29 added. 2.00 July 2011 Dermorphin Added as Class 1, Penalty A 3, 12 3,4-methylenedioxy-pyrovalerone, 2.00 July 2011 Added as Class 1, Penalty A 1, 12 aka MDPV, “Bath Salts” 2.00 July 2011 Synthetic cannabis Added as Class 1, Penalty A 10, 12 2.00 July 2011 Alclomethasone Corrected typographical error in spelling 1, 22 Corrected typographical error on Penalty Class from Class B to 1.01 January 2011 Methocarbamol 7, 23 Class C 1.00 December 2010 Zilpaterol Added as Class 3, Penalty a 11, 17 1.00 December 2010 Dimethylsulfoxide (DMSO) Changed from Class 5 to Class 4 4, 23

Association of Racing Commissioners International, Inc. Page 35 Uniform Classification Guidelines for Foreign Substances

Version 11.00 - Revised December 2015